{"symbol":"ARNT","synonyms":["HIF-1BETA","HIF1BETA","HIF1B","HIF-1-BETA","TANGO","HIF1-BETA","BHLHE2"],"name":"aryl hydrocarbon receptor nuclear translocator","description":"This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]","ncbiEntrezGeneId":405,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/405","proteins":[{"symbol":"ARNT_HUMAN","href":"/api/1.0/protein/ARNT_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"}]}