{"symbol":"ARRB2","synonyms":["ARB2","ARR2","BARR2"],"name":"arrestin, beta 2","description":"Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":409,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/409","proteins":[{"symbol":"ARRB2_HUMAN","href":"/api/1.0/protein/ARRB2_HUMAN"}],"hgncRootFamilies":[]}