{"symbol":"ASB2","synonyms":["ASB-2"],"name":"ankyrin repeat and SOCS box containing 2","description":"This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]","ncbiEntrezGeneId":51676,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51676","proteins":[{"symbol":"ASB2_HUMAN","href":"/api/1.0/protein/ASB2_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}