{"symbol":"ASB7","synonyms":[],"name":"ankyrin repeat and SOCS box containing 7","description":"The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":140460,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/140460","proteins":[{"symbol":"ASB7_HUMAN","href":"/api/1.0/protein/ASB7_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}