{"symbol":"ASIC2","synonyms":["HBNAC1","MDEG","ACCN","ASIC2A","BNAC1","BNC1","ACCN1"],"name":"acid sensing (proton gated) ion channel 2","description":"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]","ncbiEntrezGeneId":40,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/40","proteins":[{"symbol":"ASIC2_HUMAN","href":"/api/1.0/protein/ASIC2_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}