{"symbol":"ASPM","synonyms":["MCPH5","CALMBP1"],"name":"asp (abnormal spindle) homolog, microcephaly associated (Drosophila)","description":"This gene is the human ortholog of the Drosophila melanogaster \u0027abnormal spindle\u0027 gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]","ncbiEntrezGeneId":259266,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/259266","proteins":[{"symbol":"ASPM_HUMAN","href":"/api/1.0/protein/ASPM_HUMAN"}],"hgncRootFamilies":[]}