{"symbol":"ATF4","synonyms":["CREB2","CREB-2","TAXREB67","TXREB"],"name":"activating transcription factor 4","description":"This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":468,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/468","proteins":[{"symbol":"ATF4_HUMAN","href":"/api/1.0/protein/ATF4_HUMAN"}],"hgncRootFamilies":[{"name":"Basic leucine zipper proteins","href":"/api/1.0/gene_family/Basic+leucine+zipper+proteins"}]}