{"symbol":"ATF6B","synonyms":["CREBL1","CREB-RP"],"name":"activating transcription factor 6 beta","description":"The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":1388,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1388","proteins":[{"symbol":"ATF6B_HUMAN","href":"/api/1.0/protein/ATF6B_HUMAN"}],"hgncRootFamilies":[{"name":"Basic leucine zipper proteins","href":"/api/1.0/gene_family/Basic+leucine+zipper+proteins"}]}