{"symbol":"ATIC","synonyms":["PURH","AICAR","HEL-S-70P","AICARFT","IMPCHASE"],"name":"5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase","description":"This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":471,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/471","proteins":[{"symbol":"PUR9_HUMAN","href":"/api/1.0/protein/PUR9_HUMAN"}],"hgncRootFamilies":[]}