{"symbol":"ATP1A2","synonyms":["FHM2","MHP2"],"name":"ATPase, Na+/K+ transporting, alpha 2 polypeptide","description":"The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":477,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/477","proteins":[{"symbol":"AT1A2_HUMAN","href":"/api/1.0/protein/AT1A2_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}