{"symbol":"ATP1B4","synonyms":[],"name":"ATPase, Na+/K+ transporting, beta 4 polypeptide","description":"This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]","ncbiEntrezGeneId":23439,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23439","proteins":[{"symbol":"AT1B4_HUMAN","href":"/api/1.0/protein/AT1B4_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}