{"symbol":"ATP6AP1","synonyms":["ATP6IP1","ATP6S1","XAP-3","CF2","XAP3","16A","VATPS1","AC45"],"name":"ATPase, H+ transporting, lysosomal accessory protein 1","description":"This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]","ncbiEntrezGeneId":537,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/537","proteins":[{"symbol":"VAS1_HUMAN","href":"/api/1.0/protein/VAS1_HUMAN"}],"hgncRootFamilies":[]}