{"symbol":"ATP6V0B","synonyms":["VMA16","ATP6F","HATPL"],"name":"ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b","description":"This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]","ncbiEntrezGeneId":533,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/533","proteins":[{"symbol":"VATO_HUMAN","href":"/api/1.0/protein/VATO_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}