{"symbol":"ATP6V0C","synonyms":["ATPL","ATP6L","VATL","ATP6C","VPPC","VMA3"],"name":"ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c","description":"This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\u0027, c`, and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]","ncbiEntrezGeneId":527,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/527","proteins":[{"symbol":"VATL_HUMAN","href":"/api/1.0/protein/VATL_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}