{"symbol":"ATP6V1C2","synonyms":["ATP6C2"],"name":"ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2","description":"This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":245973,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/245973","proteins":[{"symbol":"VATC2_HUMAN","href":"/api/1.0/protein/VATC2_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}