{"symbol":"ATP6V1F","synonyms":["VATF","ATP6S14","VMA7"],"name":"ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F","description":"This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\u0027, c`, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9296,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9296","proteins":[{"symbol":"VATF_HUMAN","href":"/api/1.0/protein/VATF_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}