{"symbol":"AVPR1B","synonyms":["V1bR","AVPR3"],"name":"arginine vasopressin receptor 1B","description":"The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":553,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/553","proteins":[{"symbol":"V1BR_HUMAN","href":"/api/1.0/protein/V1BR_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}