{"symbol":"AXIN1","synonyms":["AXIN","PPP1R49"],"name":"axin 1","description":"This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":8312,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8312","proteins":[{"symbol":"AXIN1_HUMAN","href":"/api/1.0/protein/AXIN1_HUMAN"}],"hgncRootFamilies":[{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}