{"symbol":"B2M","synonyms":["IMD43"],"name":"beta-2-microglobulin","description":"This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]","ncbiEntrezGeneId":567,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/567","proteins":[{"symbol":"B2MG_HUMAN","href":"/api/1.0/protein/B2MG_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}