{"symbol":"BACE2","synonyms":["AEPLC","ASP1","DRAP","ALP56","ASP21","BAE2","CEAP1","CDA13"],"name":"beta-site APP-cleaving enzyme 2","description":"This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer\u0027s disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":25825,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25825","proteins":[{"symbol":"BACE2_HUMAN","href":"/api/1.0/protein/BACE2_HUMAN"}],"hgncRootFamilies":[]}