{"symbol":"BAG3","synonyms":["MFM6","CAIR-1","BIS","BAG-3"],"name":"BCL2-associated athanogene 3","description":"BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9531,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9531","proteins":[{"symbol":"BAG3_HUMAN","href":"/api/1.0/protein/BAG3_HUMAN"}],"hgncRootFamilies":[]}