{"symbol":"BBC3","synonyms":["PUMA","JFY1","JFY-1"],"name":"BCL2 binding component 3","description":"This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":27113,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27113","proteins":[{"symbol":"BBC3B_HUMAN","href":"/api/1.0/protein/BBC3B_HUMAN"}],"hgncRootFamilies":[]}