{"symbol":"BCL11A","synonyms":["BCL11A-L","BCL11A-M","BCL11A-XL","ZNF856","EVI9","CTIP1","BCL11A-S","HBFQTL5","DILOS"],"name":"B-cell CLL/lymphoma 11A (zinc finger protein)","description":"This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":53335,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/53335","proteins":[{"symbol":"BC11A_HUMAN","href":"/api/1.0/protein/BC11A_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}