{"symbol":"BCL3","synonyms":["D19S37","BCL4"],"name":"B-cell CLL/lymphoma 3","description":"This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":602,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/602","proteins":[{"symbol":"BCL3_HUMAN","href":"/api/1.0/protein/BCL3_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}