{"symbol":"BCL6","synonyms":["LAZ3","ZNF51","BCL5","BCL6A","ZBTB27"],"name":"B-cell CLL/lymphoma 6","description":"The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":604,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/604","proteins":[{"symbol":"BCL6_HUMAN","href":"/api/1.0/protein/BCL6_HUMAN"}],"hgncRootFamilies":[{"name":"BTB (POZ) domain containing (BTBD)","href":"/api/1.0/gene_family/BTB+%28POZ%29+domain+containing+%28BTBD%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}