{"symbol":"BFAR","synonyms":["RNF47"],"name":"bifunctional apoptosis regulator","description":"Enables caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":51283,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51283","proteins":[{"symbol":"BFAR_HUMAN","href":"/api/1.0/protein/BFAR_HUMAN"}],"hgncRootFamilies":[{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}