{"symbol":"BID","synonyms":["FP497"],"name":"BH3 interacting domain death agonist","description":"This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":637,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/637","proteins":[{"symbol":"BID_HUMAN","href":"/api/1.0/protein/BID_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}