{"symbol":"BIRC3","synonyms":["C-IAP2","HAIP1","HIAP1","AIP1","MIHC","CIAP2","RNF49","MALT2","API2"],"name":"baculoviral IAP repeat containing 3","description":"This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":330,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/330","proteins":[{"symbol":"BIRC3_HUMAN","href":"/api/1.0/protein/BIRC3_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"Baculoviral IAP repeat containing (BIRC)","href":"/api/1.0/gene_family/Baculoviral+IAP+repeat+containing+%28BIRC%29"}]}