{"symbol":"BMP15","synonyms":["GDF9B","ODG2","POF4"],"name":"bone morphogenetic protein 15","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]","ncbiEntrezGeneId":9210,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9210","proteins":[{"symbol":"BMP15_HUMAN","href":"/api/1.0/protein/BMP15_HUMAN"}],"hgncRootFamilies":[{"name":"Bone morphogenetic proteins (BMP)","href":"/api/1.0/gene_family/Bone+morphogenetic+proteins+%28BMP%29"}]}