{"symbol":"BMP3","synonyms":["BMP-3A"],"name":"bone morphogenetic protein 3","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":651,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/651","proteins":[{"symbol":"BMP3_HUMAN","href":"/api/1.0/protein/BMP3_HUMAN"}],"hgncRootFamilies":[{"name":"Bone morphogenetic proteins (BMP)","href":"/api/1.0/gene_family/Bone+morphogenetic+proteins+%28BMP%29"}]}