{"symbol":"BMP7","synonyms":["OP-1"],"name":"bone morphogenetic protein 7","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":655,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/655","proteins":[{"symbol":"BMP7_HUMAN","href":"/api/1.0/protein/BMP7_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"},{"name":"Bone morphogenetic proteins (BMP)","href":"/api/1.0/gene_family/Bone+morphogenetic+proteins+%28BMP%29"}]}