{"symbol":"BMP8B","synonyms":["BMP8","OP2"],"name":"bone morphogenetic protein 8b","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":656,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/656","proteins":[{"symbol":"BMP8B_HUMAN","href":"/api/1.0/protein/BMP8B_HUMAN"}],"hgncRootFamilies":[{"name":"Bone morphogenetic proteins (BMP)","href":"/api/1.0/gene_family/Bone+morphogenetic+proteins+%28BMP%29"},{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}