{"symbol":"BPNT1","synonyms":["PIP","HEL20"],"name":"3\u0027(2\u0027), 5\u0027-bisphosphate nucleotidase 1","description":"BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase\u0027s physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10380,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10380","proteins":[{"symbol":"BPNT1_HUMAN","href":"/api/1.0/protein/BPNT1_HUMAN"}],"hgncRootFamilies":[]}