{"symbol":"BUB1B","synonyms":["BUB1BETA","MAD3L","HBUBR1","MVA1","SSK1","BUBR1"],"name":"BUB1 mitotic checkpoint serine/threonine kinase B","description":"This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":701,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/701","proteins":[{"symbol":"BUB1B_HUMAN","href":"/api/1.0/protein/BUB1B_HUMAN"}],"hgncRootFamilies":[]}