{"symbol":"C1R","synonyms":["EDSPD1"],"name":"complement component 1, r subcomponent","description":"This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome. [provided by RefSeq, Dec 2018]","ncbiEntrezGeneId":715,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/715","proteins":[{"symbol":"C1R_HUMAN","href":"/api/1.0/protein/C1R_HUMAN"}],"hgncRootFamilies":[{"name":"Complement system","href":"/api/1.0/gene_family/Complement+system"}]}