{"symbol":"C5AR1","synonyms":["CD88","C5AR","C5R1"],"name":"complement component 5a receptor 1","description":"Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer\u0027s disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":728,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/728","proteins":[{"symbol":"C5AR1_HUMAN","href":"/api/1.0/protein/C5AR1_HUMAN"}],"hgncRootFamilies":[{"name":"Complement system","href":"/api/1.0/gene_family/Complement+system"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}