{"symbol":"C8ORF4","synonyms":["C8orf4","TCIM"],"name":"chromosome 8 open reading frame 4","description":"This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]","ncbiEntrezGeneId":56892,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56892","proteins":[{"symbol":"CH004_HUMAN","href":"/api/1.0/protein/CH004_HUMAN"}],"hgncRootFamilies":[]}