{"symbol":"CA12","synonyms":["CA-XII","T18816","CAXII","HST18816"],"name":"carbonic anhydrase XII","description":"Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]","ncbiEntrezGeneId":771,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/771","proteins":[{"symbol":"CAH12_HUMAN","href":"/api/1.0/protein/CAH12_HUMAN"}],"hgncRootFamilies":[{"name":"Carbonic anhydrases (CA)","href":"/api/1.0/gene_family/Carbonic+anhydrases+%28CA%29"}]}