{"symbol":"CACNA1B","synonyms":["CAV2.2","BIII","CACNL1A5","CACNN","DYT23"],"name":"calcium channel, voltage-dependent, N type, alpha 1B subunit","description":"The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":774,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/774","proteins":[{"symbol":"CAC1B_HUMAN","href":"/api/1.0/protein/CAC1B_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"},{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}