{"symbol":"CACNA1D","synonyms":["CACH3","CCHL1A2","CAV1.3","SANDD","CACN4","PASNA","CACNL1A2"],"name":"calcium channel, voltage-dependent, L type, alpha 1D subunit","description":"Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]","ncbiEntrezGeneId":776,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/776","proteins":[{"symbol":"CAC1D_HUMAN","href":"/api/1.0/protein/CAC1D_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}