{"symbol":"CAD","synonyms":["CDG1Z","EIEE50","GATD4"],"name":"carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase","description":"The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":790,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/790","proteins":[{"symbol":"PYR1_HUMAN","href":"/api/1.0/protein/PYR1_HUMAN"}],"hgncRootFamilies":[]}