{"symbol":"CALD1","synonyms":["H-CAD","CDM","HCAD","L-CAD","NAG22"],"name":"caldesmon 1","description":"This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":800,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/800","proteins":[{"symbol":"CALD1_HUMAN","href":"/api/1.0/protein/CALD1_HUMAN"}],"hgncRootFamilies":[]}