{"symbol":"CAMLG","synonyms":["GET2","CAML"],"name":"calcium modulating ligand","description":"The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":819,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/819","proteins":[{"symbol":"CAMLG_HUMAN","href":"/api/1.0/protein/CAMLG_HUMAN"}],"hgncRootFamilies":[]}