{"symbol":"CAPN5","synonyms":["NCL-3","ADNIV","HTRA3","VRNI"],"name":"calpain 5","description":"Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":726,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/726","proteins":[{"symbol":"CAN5_HUMAN","href":"/api/1.0/protein/CAN5_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}