{"symbol":"CARD8","synonyms":["DAKAR","DACAR","NDPP","NDPP1","CARDINAL","TUCAN"],"name":"caspase recruitment domain family, member 8","description":"The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]","ncbiEntrezGeneId":22900,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22900","proteins":[{"symbol":"CARD8_HUMAN","href":"/api/1.0/protein/CARD8_HUMAN"}],"hgncRootFamilies":[]}