{"symbol":"CARS","synonyms":["CYSRS","CARS1","MGC:11246"],"name":"cysteinyl-tRNA synthetase","description":"This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]","ncbiEntrezGeneId":833,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/833","proteins":[{"symbol":"SYCC_HUMAN","href":"/api/1.0/protein/SYCC_HUMAN"}],"hgncRootFamilies":[{"name":"Aminoacyl tRNA synthetases","href":"/api/1.0/gene_family/Aminoacyl+tRNA+synthetases"}]}