{"symbol":"CASP2","synonyms":["ICH1","NEDD-2","PPP1R57","CASP-2","NEDD2"],"name":"caspase 2, apoptosis-related cysteine peptidase","description":"This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer\u0027s disease, Huntington\u0027s disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]","ncbiEntrezGeneId":835,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/835","proteins":[{"symbol":"CASP2_HUMAN","href":"/api/1.0/protein/CASP2_HUMAN"}],"hgncRootFamilies":[{"name":"Caspases (CASP)","href":"/api/1.0/gene_family/Caspases+%28CASP%29"},{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}