{"symbol":"CAST","synonyms":["BS-17","PLACK"],"name":"calpastatin","description":"The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]","ncbiEntrezGeneId":831,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/831","proteins":[{"symbol":"ICAL_HUMAN","href":"/api/1.0/protein/ICAL_HUMAN"}],"hgncRootFamilies":[]}