{"symbol":"CBFA2T3","synonyms":["MTGR2","MTG16","RUNX1T3","ZMYND4","ETO2"],"name":"core-binding factor, runt domain, alpha subunit 2; translocated to, 3","description":"This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5\u0027-region of the runt-related transcription factor 1 gene fused to the 3\u0027-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]","ncbiEntrezGeneId":863,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/863","proteins":[{"symbol":"MTG16_HUMAN","href":"/api/1.0/protein/MTG16_HUMAN"}],"hgncRootFamilies":[{"name":"A-kinase anchor proteins (AKAP)","href":"/api/1.0/gene_family/A-kinase+anchor+proteins+%28AKAP%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}