{"symbol":"CBX5","synonyms":["HEL25","HP1A"],"name":"chromobox homolog 5","description":"This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":23468,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23468","proteins":[{"symbol":"CBX5_HUMAN","href":"/api/1.0/protein/CBX5_HUMAN"}],"hgncRootFamilies":[]}